How is the conformational dynamics of mammalian FAS coordinated with catalysis? Recent structural insights have begun to reveal how conformational transitions in mFAS influence catalytic efficiency and domain–domain communication.
This review dives into the latest breakthroughs uncovering the structural and conformational secrets of mammalian fatty acid synthase (FAS). Instead of providing a broad overview, we spotlight the remarkable dynamic shifts that FAS undergoes as it drives the fatty acid synthesis cycle forward.
Link to review: https://doi.org/10.1016/j.tibs.2025.09.005